Quick Index
 Adult Industry News
Search AINews Database
Type Keyword or Phrase Here
Are you TOUGH ENOUGH for Joanna Angel? EXPO 2014, August 24-27, Mandalay Bay, Las Vegas
   
 

Front Page
Film News
Media News
Business News
Clubs & Appearances
Law & Politics
Internet & Mobile News
Lifestyles Arts Health Charity
Letters to the Editor
Columns
Movie Spotlight Reviews
Interviews
Pornstar Pages
AINews Staff
Ad Rates
PR 101: Press Release Service

Caliente Nudist Vacations!

Kayden Kross at Twistys

April 18, 2001 05:35am
HIV Vaccine Research Symposium in Keystone, CO Highlights Merck & Co.'s HIV Vaccine Research Program
Source: Donner Corp. International
by: Company Press Release

(SANTA ANA, CA) -- Donner Corp. International, a broker/dealer headquartered in Santa Ana, CA., today issued a Morning Call Note on CytRx Corp., Norcross, Georgia (Nasdaq: CYTR - news). CytRx is a biotechnology company with a phase III product, FLOCOR(TM), under development for the treatment of sickle cell disease patients suffering from vaso-occlusive crisis.

The Morning Call Notes is as follows:

Scientists at Merck & Co. (NYSE: MRK - news) developed 5 different formulations of vaccines against HIV: one using DNA inserted into a modified and non-replicating adenovirus, one using DNA inserted into a modified vaccinia virus, and three formulations of ``naked'' DNA, one of which included CytRx's CRL-1005, also known as TRANZFECT. (Source: Washington Post, April 2, 2001). The ``naked'' DNA used in the Merck program employed the naked DNA gene delivery technology developed by Vical, Inc. of San Diego, California (Nasdaq: VICL - news). (Source: Vical, Inc. press release, April 2, 2001). The DNA fragment used was the segment called ``gag,'' which encodes various internal group-specific antigens. Gag would get inserted into a host cell via a viral or non-viral vector, and the host cell's machinery would transcribe it so that the gag proteins are expressed. Because these gag proteins are foreign, they would elicit a cell mediated immune response in the form of killer cells (natural killer cells, killer T cells, macrophages), which would destroy cells that express the gag proteins: HIV-infected cells.

After two months, the monkeys that received the DNA vaccine delivered via the adenovirus exhibited undetectable HIV levels in the blood. Their CD4 cell (an immune response cell) count also returned to normal numbers. A similar, but less dramatic, response was seen in monkeys who were vaccinated with ``naked'' DNA + CRL-1005 (TRANZFECT). (Source: Washington Post, April 2, 2001). Dr. John W. Shiver, director of vaccine research at Merck & Co., said that the vaccine administered via the modified adenovirus did not prevent infection, but limited the number of viral copies to 100 to 1000 times less than the amount of HIV seen in the monkeys given the other vaccines prototypes, excluding the CRL-1005-coated DNA, which also resulted in undetectable HIV levels in the blood. (Source: USA Today, April 2, 2001). Merck & Co.'s strategy may be to prime people with the DNA vaccine + CRL-1005 and then boost their immune responses with the DNA vaccine in the adenovirus vector. (Source: WebMD, April 4, 2001; USA Today, April 2, 2001; The Wall Street Journal, April 2, 2001).

Such early data from a pharmaceutical giant like Merck suggest that the TRANZFECT (CRL-1005) platform has promising potential. It is interesting to note that this ``second best'' vaccine in this DNA vaccine program used the same ``naked'' DNA as the other two ``naked'' DNA vaccines, which were not as successful. Those other two ``naked'' DNA vaccines, which were constructed using Vical, Inc.'s patented ``naked'' DNA gene delivery technology, were not ``coated'' with CytRx's TRANZFECT (CRL-1005) technology. CRL-1005 comes from a family of poloxamers, which are synthetic polymer coats developed by CytRx. When applied to ``naked'' DNA fragments, these synthetic polymers coat the ``naked'' DNA to form microparticles that can fuse to the host cell's cell membrane and insert the DNA fragment. Other indications that CytRx is developing for these poloxamers are muscular dystrophy, spinal cord injury, and animal feed additives that enhance growth in animals. (The last indication is licensed to Ivy Animal Health, Inc. of Overland Park, Kansas). CytRx received $2 million from Merck & Co. for the exclusive, worldwide license to use CytRx's TRANZFECT technology in DNA-based vaccines targeted to 4 infectious diseases, one of which is HIV. CytRx will receive an additional $1 million if Merck takes its HIV DNA vaccine + CRL-1005 formulation into phase I of clinical trials. An additional $1 million would follow if this formulation enters phase IIb or phase III clinical trials.

Donner Corp. initiated coverage on CytRx Corp. on April 10, 2001 with a Speculative Buy rating.

Copies of the April 10, 2001 report on CytRx Corp. are available from Donner Corp. at www.donnercorp.com.

Donner Corp. International (DCI) is a member of the National Association of Securities Dealers, CRD number 37702. Any information or opinion provided in this press release does not solicit or make an offer to buy or sell any securities or any options, futures or other derivatives related to such securities herein. DCI and its affiliates may trade for their own accounts in any securities of the issuer or in related securities. DCI or its affiliates, directors, officers and employees, may have a long or short position in securities of the issuer or related investments. DCI or its affiliates may from time to time perform investment banking or other services for, or solicit investment banking or other business from, any entity mentioned in this press release. This press release has been prepared for general circulation and is circulated for general information only. It does not have regard to the specific investment objective, financial situation, suitability, and the particular need of any specific person who may receive this press release. Investors should seek financial advice regarding the appropriateness of investing in any securities or investment strategies discussed or recommended in this press release and should understand that statements regarding future prospects may not be realized. Investors should note that income from such securities, if any, may fluctuate and that each security's price or value may rise or fall substantially. Accordingly, investors may receive back less than originally invested. Past performance is not indicative of future performance. DCI receives monthly fees for various services provided and may receive stock compensation at a future date.

Are you TOUGH ENOUGH for Joanna Angel?


Related Sites - WARNING! Graphic Content

RavenBay01.3gp

See BiBi Jones at Digital Playground

Top Stories

MWA: 07/23/14

MWA: 07/22/14

MWA: 07/21/14

Tweets = Cash with PornPitch

Proud Parents ~ Reviewer Rated

RNSU July 17

Next Day Test in LV

MWA: 07/13/14

Condomless Sex

The Goddess Lives

A Legend Looks Back

Nikki Phoenix Hosts Palomino

RNSU Thurs July 10

Nikki Delano at Crazy Horse

Resurgence of the Goddess

Pornstar Graduates Law School

July 3 Rock-N-SeXXXy-Uncencored

More on Belle Knox

Morgan Del Ray Karaoke XXX

MWA: 05/21/14

The Temptation of Eve ~ Reviewer Rated

Cumisha Amado on Vivid Radio

Yoga for Lovers

She's Judas & Available

Nikki Delano on Jukeboxx

Lapdance Lingerie in Neighbors

XRCO Welcomes Rich Hansen

IIM Party June 13

Hustler EDM Maniac Party

Layla Price Stars

Julia Sands Karaoke XXX

Susana Molina in Baci Lingerie

Fetish Con Dates

Porn's Greatest Star

James Deen June Promo

Exxxotica Exhibitors Lining Up

AdultVerifiedVideoChat iPad Contest

Sunny Leone Hosts Splitsvilla

Porn Star Game Night

Camming Con Moves Dates

Discount Club Owners Expo Tickets

Teal Conrad at Sapphire NYC

Exquisite Distributes DDF

Cherie Deville Returns

Alana Evans at WonderCon

Risque Starr Sisters Parties

Natasha Voya PSK

The Sexual Liberation of Anna Lee ~ Reviewer Rated

Carter Cruise at Exxxotica

Belle Knox at Exxxotica

Rock'N'SeXXXy & Hustler

Puma Swede Opens Desire

Nikki Phoenix XRCO Nom

Maddy O'Reilly is Slutwoman

Alex Chance jGrrl

Tony Batman Conquers LA

Alexa Aimes NYC Tour

2014 AVN News Rack Part 2

Roxanne Rae Available

Minka Karaoke XXX

Rio Lee Heads Cherry Pimps

Immoral Mayhem

XRCO Sponsorship Opportunities

Rotten Hosting Vivid Radio

Cherie Deville Available

Tony Batman Crazy Appearances

Inside The Industry 03/19/2014

Chanel Preston Interview

Alicia Silver Productions Content

Adrianna Luna Dance Dates

Entertainment is Entertainment is Entertainment

More
Stories From

Lifestyles Arts Health Charity

Next Day Test in LV

Condomless Sex

Fetish Con Dates

Gloria Leonard Memorial

Valentine's Tips

Kinky Valentine Cards

Dammit He's Dead

Death at Bunny Ranch

Sara Jay not Dead

Glory Stories Batts Fundraiser

Daisy Marie hosts Philippines Relief

Fairvilla Movember Bash

Nadia Night Back From Rehab

Altar dedicated to Guccione

Alex Gonz Hep C Statement

CSC Preserves AIDS Poster

Bible Study with Kurt Lockwood

CineKink Screens at BedFEST

Shibari Speaks at Woodhull

Baci Launches Halloween Contest

ASACP to London XBIZ EU

Wicked Heads AIDS Walk

Yahshua Seeks Help

Alesia Pleasure at Bare Bowling

LATATA Hep C Statement

Bare Bowling is Back

LATATA Advises Performers

drake Leads AIDS Walk

CineKink in Oakland

CineKink Kicks Off

Vice is Nice Charity Event

CineKink 2013 Tour Dates

Simone Takes Art World

Sandau Scholarship Fund Established

1000 Bras to Tornado Victims

Paris Kennedy Sanctuary Sessions

CatalystCon West Pre-Con Events

Wrestle Erotica Celebrity Fundraiser

Sexploitation Documentary

CET Screens for Hep

Rockstar Mayhem Festival Update

Priya Rai Retirement, Engagement

Superman Super Show

Monet Helps Hurricane Victims

Deep Throat Sex Scandal Movie

Ropes with Julie Simone

Gamelink to Senator Robert Ford

CatalystCon Speakers, Sponsors

Bondage Ball Hollywood

Sportsheets at Pride Event

Toga Lifestyle Party

Domcon LA This Week

Kurt Lockwood at Ice House

2013 Masturbate-a-Thon

Angel Sponsors AIDS Research

     
Copyright © 1998 - 2014 Adult Industry News (AINews.com)
All materials constituting text, articles, press releases, stories, columns, photographs, graphics, and code on the AINews.com domain are protected by copyright, and either owned by Adult Industry News (AINews.com), or reproduced with permission from other copyright owners. It may be downloaded and printed for personal reference, but not otherwise copied, altered in any way, or transmitted to others, without the written permission of Adult Industry News (AINews.com).